The Department of Chemistry was established in 1977 as a branch of the College of Education at King Saud University in Abha. In 1998, the two university branches in the Asir region, namely, the Imam Muhammad bin Saud Islamic University branch and King Saud University branch, were merged into one university called King Khalid University. Consequently, the College of Education at King Khalid University was renamed as the College of Science where Department of Chemistry was kept as one of its departments.

The Department of Physics was established in 1396 H as one of the Departments of the College of Education, King Saud University branch in Abha. The first graduates graduated in 1400–1401 H. When King Khalid University was established in the academic year 1419–1420 H the Department of Physics became a part of the Faculty of Science at King Khalid University departments. Many students have graduated from the Department since its inception and joined various government or private jobs.

The Department of Mathematics was established in 1397H-1977 within the departments of the College of Education as a branch of King Saud University in Abha. After the Supreme Decree No. 7/78/M dated 11-03-1419H establishing King Khalid University, the Department of Mathematics became part of the College of Science. 

In the name Allah
Praise be to Allah says in the Holy Qur'an "Do deeds! Allah will see your deeds, and (so well) His Messenger and the believers". And Peace and blessings on human teacher "Mohammed" and his Family.